Atherosclerosis-Susceptible and Atherosclerosis-Resistant Pigeon Aortic Smooth Muscle Cells Express Different Genes and Proteins in vitro
نویسندگان
چکیده
This review describes theories of human atherogenesis and experimental results evaluating gene or protein expression in the pigeon model for spontaneous atherosclerosis. The spontane‐ ous disease in the pigeon differentiates from other animal models that require manipulation (genetic, nutritional, environmental) to induce the disease state. Both susceptible and resistant pigeons have been studied with susceptibility being inherited as an autosomal recessive trait. The aims are to present the pigeon data in comparison to current theories of the human disease.
منابع مشابه
Atherosclerosis-susceptible and atherosclerosis-resistant pigeon aortic cells express different genes in vivo.
Spontaneous atherosclerosis in the White Carneau (WC-As) pigeon is inherited as a single gene disorder, and its progression closely mirrors the human disease. Representational difference analysis and microarray were used to identify genes that were differentially expressed between the susceptible WC-As and resistant Show Racer (SR-Ar) aortic tissue. The RNA extracted from 1-d-old squab aortas w...
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